Padhi Research Group
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Professor
Biocatalysis and Enzyme Engineering Laboratory
Department of Biochemistry
School of Life Sciences
University of Hyderabad
Hyderabad 500046, India
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Phone: 040-6679-4522
Email: skpadhi@uohyd.ac.in
Our Research
Nature has evolved enzymes with unique catalytic power. We are aiming to learn the catalysis and chemistry of enzymes from nature and apply them in the benefit of mankind. Our focus is on laboratory evolution of enzymes for green synthesis of asymmetric molecules of biological and pharmaceutical significance.
Our group is working on Biocatalysis, an interdisciplinary science where Green Chemistry, Asymmetric Synthesis, Enzyme Catalysis, and Molecular Biology meet. ​
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Our Tagline
Explore the Science and play around Enzymes
Publication Highlights
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Kinetic vs Thermodynamic Controlled Promiscuous Biocatalytic Asymmetric Henry Reaction in Diastereocomplementary Synthesis of β-Nitroalcohols
Ayon Chatterjee, Pradeep Kumar Pal, U. Deva Priyakumar, Santosh Kumar Padhi
​ACS Catalysis, 2025, 15, 9682-9694. doi/full/10.1021/acscatal.5c01752​
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Uncovering Hydroxynitrile Lyase Variants with Promiscuous Diastereoselective Nitroaldolase Activity Towards Highly Stereocontrolled Synthesis of anti β-Nitroalcohols.
Ayon Chaterjee, G. Priyanka, N. Prakash Prabhu, and Santosh Kumar Padhi
ACS Catalysis, DOI: https://doi.org/10.1021/acscatal.4c04000 ACS Catal. 2024, 14, 12623−12634
Addition/correction: ACS Catal. 2024, 14, 18406-18407 doi.org/10.1021/acscatal.4c06888
A Single Enzyme in Enantiocomplementary Synthesis of β-Nitroalcohols: Bidirectional Catalysis by Hydroxynitrile Lyase
Sukadev Rana, Ayon Chatterjee, Santosh Kumar Padhi
ChemBioChem, https://doi.org/10.1002/cbic.202400618
Hydroxynitrile lyase engineering for promiscuous asymmetric Henry reaction with enhanced conversion, enantioselectivity and catalytic efficiency
Badipatla Vishnu Priya, D. H. Sreenivasa Rao, Ayon Chatterjee, Santosh Kumar Padhi
Chem. Commun., 2023, DOI: 10.1039/D3CC02837B.
Lab values
Our laboratory is committed to creating a welcoming, supportive, and collaborative environment where everyone feels valued and respected. We encourage open communication, teamwork, and the sharing of ideas, recognizing that diverse perspectives enrich our research. We ask all members to treat one another with kindness, professionalism, and consideration, and to contribute to a positive and inclusive research culture.
Vacancies
Interested candidates are welcome
Ph.D
3 positions
Research Associate
1 position
Research Assistant
Nil
Address
Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad-500046, India